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-indazoles 1a–m with distinct substituted aldehydes 2a–q/benzyl alcohols 5a–e/styrenes 6a–e in as many as 87% yields.QT Shortening: XCOPRI could cause shortening from the QT interval. Warning ought to be used when administering XCOPRI as well as other drugs that shorten the QT interval as there may be a synergistic effect on the QT interval